منابع مشابه
Linking spindle to furrow
olarizing cells must first pick a direction. The external cues that guide this choice are obvious: bud scars or mating partners for budding yeast, and chemoattractant gradients for Dictyostelium and neutrophils. But polarization still occurs, albeit in a random direction, when these cues are either removed or made uniform. Now, Roland Wedlich-Soldner, Rong Li (Harvard Medical School, Boston, MA...
متن کاملVesicles and actin are targeted to the cleavage furrow via furrow microtubules and the central spindle
During cytokinesis, cleavage furrow invagination requires an actomyosin-based contractile ring and addition of new membrane. Little is known about how this actin and membrane traffic to the cleavage furrow. We address this through live analysis of fluorescently tagged vesicles in postcellularized Drosophila melanogaster embryos. We find that during cytokinesis, F-actin and membrane are targeted...
متن کاملA spindle-independent cleavage furrow positioning pathway
The mitotic spindle determines the cleavage furrow site during metazoan cell division, but whether other mechanisms exist remains unknown. Here we identify a spindle-independent mechanism for cleavage furrow positioning in Drosophila neuroblasts. We show that early and late furrow proteins (Pavarotti, Anillin, and Myosin) are localized to the neuroblast basal cortex at anaphase onset by a Pins ...
متن کاملPAR-4 and anillin regulate myosin to coordinate spindle and furrow position during asymmetric division
During asymmetric cell division, the mitotic spindle and polarized myosin can both determine the position of the cytokinetic furrow. However, how cells coordinate signals from the spindle and myosin to ensure that cleavage occurs through the spindle midzone is unknown. Here, we identify a novel pathway that is essential to inhibit myosin and coordinate furrow and spindle positions during asymme...
متن کاملAugmin shapes the anaphase spindle for efficient cytokinetic furrow ingression and abscission
During anaphase, distinct populations of microtubules (MTs) form by either centrosome-dependent or augmin-dependent nucleation. It remains largely unknown whether these different MT populations contribute distinct functions to cytokinesis. Here we show that augmin-dependent MTs are required for the progression of both furrow ingression and abscission. Augmin depletion reduced the accumulation o...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2003
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb1605rr4